Monthly Archives: January 2022

Study shows mRNA booster dose eliminates immune escape observed with SARS-CoV-2 Omicron

Researchers examined total and neutralizing antibodies to the spike protein of SARS-CoV-2, and neutralizing antibodies against Washington-1 (WA-1) and variants of concern (VOC) including Beta, Delta, and Omicron in a longitudinal cohort.

Researchers develop new technique to open the blood-brain barrier in lab animals

University of Maryland School of Medicine researchers developed a technique in laboratory animals to consistently and reproducibly open the blood-brain barrier.

Observational study reveals continuing inequality in COVID-19 mortality in England and Wales

Recently, the same group of researchers refined their earlier analysis by using new data sets to determine deaths due to COVID-19 instead of including deaths involving COVID-19 in small areas. This study has been posted to the medRxiv* preprint server.

Study highlights importance of immunizing and boosting PAD syndromes patients with SARS-CoV-2 mRNA vaccines

A new study posted to the medRxiv* preprint server has evaluated the effect of mRNA-based COVID-19 vaccination and boosting strategy on serum antibody responses in PAD patients against the original SARS-CoV-2 strain and circulating variants.

Fusion oncogenes associated with more invasive pediatric thyroid cancers, study says

Fusion oncogenes, such as RET- and NTRK-gene fusions, are associated with more invasive pediatric thyroid cancers, correlating with the highest risk of metastases and a lower likelihood of achieving remission one year after initial therapy, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP).

Researchers visualize protein machinery of respiration for the first time

Oxygen and sugar are the basis of life for animals, plants, fungi and many bacteria. The metabolic process called respiration makes it possible to convert food into energy for the cells.

Dexamethasone administration at a late time point could enhance transgene expression

Dexamethasone, a glucocorticoid with anti-inflammatory and immunosuppressive effects, can transiently increase the expression of therapeutic genes delivered using adeno-associated virus (AAV) vectors.

Vaccination as a condition of deployment for health, social care staff revisited as Omicron replaces Delta

Regulations making vaccines a condition of deployment for health and social care staff are set to be revoked, subject to public consultation and parliamentary approval, the Health and Social Care Secretary has announced.