Inverted order: The direction of your DNA may be as important as which parent it came from

Researchers generated mice with a specific DNA sequence inverted to determine if orientation affects expression of a gene called H19. Expression can also be impacted if the surrounding DNA is altered by a process called methylation. Interestingly, methylation was only relevant when the inverted sequence was inherited from the father. When inherited from the mother, the inversion had the opposite effect on H19 expression, suggesting a more complex mechanism is at play.