STAT+: Data show strong results for Alnylam therapy for heart disease, but magnitude of benefit will stir debate

Detailed data from a successful heart disease study show a therapy developed by Alnylam Pharmaceuticals performed significantly better than placebo, but the magnitude of its benefit will stir debate among cardiologists and investors on what could be a blockbuster medicine.

In results from a yearlong study presented Thursday, Alnylam’s intravenous drug helped patients with ATTR-CM, a progressive heart disease, walk about 14.7 meters more over the course of six minutes compared to those who got placebo. The so-called six-minute walk test is an accepted metric in cardiovascular medicine, one that correlates with whether a given treatment can prevent hospitalization and death in the long term.

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