Virtual drug screening identifies possible new antidepressants in LSD-like molecules

What’s a hallucinogen without the hallucinations? Perhaps a potent and fast-acting antidepressant, according to a new study based on virtual drug screening.

Psychedelic drugs are now widely understood to have striking antidepressant effects, so a group of computational biologists sought to determine whether any new, LSD-adjacent molecules might have other medicinal powers. In work published Wednesday in Nature, the scientists used in silico modeling, generating 3D iterations of more than 75 million related molecules that don’t actually exist, but could.

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