Study of trans men suggests that androgen hormone therapy can lower breast cancer risk

When transgender men transition, their risk for breast cancer tends to plummet and look more like the breast cancer risk for cisgender men, excluding those with high-risk mutations like BRCA1 or BRCA2. Many researchers thought the main reason for this was probably breast removal during chest reconstruction surgery, but recent research suggests that the androgens during hormone replacement therapy may also play a crucial role in reshaping transgender men’s breast cancer risk.

That’s hinted to researchers that androgens, the male sex hormones, might offer new paths to develop powerful therapies to treat or prevent breast cancer.

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